Juventus were able to win their sixth game in a row at home in Serie A with a possible season defining win over Napoli.
The hosts took the lead in the opening seconds of the match with Fernando Llorente continuing his good run of form with a goal before Pirlo struck from a free-kick and Pogba added a third.
The only bad thing to come out of the game for the Black and White was the sending off of Angelo Ogbonna.
Goals and key events:2' Fernando Llorente
74' Andrea Pirlo
80' Paul Pogba